Botox vs Dysport vs Xeomin: What’s the Difference?

When it comes to smoothing fine lines and wrinkles, three neuromodulators dominate the conversation: Botox, Dysport, and Xeomin. Though all three are FDA-approved and derived from botulinum toxin type A, they’re not identical. Understanding their differences can help you make the best choice for your skin and your goals.

At Daily Glow Spa in San Diego, our holistic approach to aesthetic medicine means we don’t believe in one-size-fits-all solutions. With the guidance of Dr. Lan Nguyen, an orthopedic traumatologist and wellness expert, we offer a medically-informed yet personalized approach to facial aesthetics. Here’s everything you need to know about these three popular wrinkle-relaxers.

What Do Botox, Dysport, and Xeomin Have in Common?

All three products:

  • Temporarily relax muscle activity to soften the appearance of dynamic wrinkles (those caused by movement).
  • Are minimally invasive injectables, performed in-office with little to no downtime.
  • Are used in areas like the forehead, frown lines (glabellar lines), and crow’s feet.
  • Last an average of 3 to 4 months, although this can vary by product and patient.

But even with these shared traits, the differences in formulation, diffusion, onset, and cost make each product uniquely suited for certain individuals and treatment areas.

Botox: The Household Name

Botox, developed by Allergan, is the most well-known neuromodulator and has been used for both cosmetic and medical purposes for over 20 years.

Key Features:

  • Formulation: Contains protective proteins surrounding the active botulinum toxin.
  • Onset: Results typically appear within 3–5 days, with full effects in about 7–10 days.
  • Precision: Offers very targeted results, ideal for small treatment areas like the glabella (between the brows).
  • FDA Approval: Approved for forehead lines, frown lines, and crow’s feet.

Best For:

Patients looking for a tried-and-true option with a long history of safety and precision, especially in smaller or more detailed facial zones.

Dysport: A Softer, Quicker Solution

Dysport, developed by Ipsen and distributed in the U.S. by Galderma, is often favored for treating larger surface areas.

Key Features:

  • Formulation: Has smaller protein molecules, allowing it to spread more easily.
  • Onset: Fast-acting—results can appear in as little as 24–48 hours.
  • Diffusion: More spreadable, making it ideal for larger areas like the forehead.
  • FDA Approval: Primarily for glabellar lines.

Best For:

Clients who want quicker results or need treatment in broader areas, and those with moderate to severe forehead lines.

Xeomin: The Pure Toxin

Xeomin, manufactured by Merz, is known as the “naked injectable” because it does not contain any accessory proteins—just pure botulinum toxin type A.

Key Features:

  • Formulation: Free from complexing proteins, which reduces the risk of resistance over time.
  • Onset: Effects typically start within 3–4 days, similar to Botox.
  • Longevity: Similar to both Botox and Dysport in terms of how long it lasts.
  • FDA Approval: For glabellar lines.

Best For:

People who may have developed a tolerance to Botox or Dysport, or who prefer a product with no additives. It’s also ideal for sensitive patients who want a cleaner formulation.

Which Product Is Right for You?

There’s no universal answer because your facial anatomy, aesthetic goals, past treatments, and muscle strength all influence the decision. At Daily Glow Spa, we tailor each treatment to your personal needs with expert guidance from Dr. Lan Nguyen.

Here are a few considerations we help patients explore:

  • First-time patient? Botox may be a good baseline for measuring results.
  • Want fast results? Dysport can kick in quicker.
  • Prefer a more natural product? Xeomin’s purity may be ideal.
  • Already tried one product? We’ll help determine if switching may provide better outcomes.

A personalized consultation ensures you not only choose the best product, but receive it in the most strategic way for lasting, natural-looking results.

Safety and Side Effects

All three injectables are considered safe when administered by trained professionals. Mild side effects like redness, swelling, or bruising at the injection site are common but usually resolve within a few days.

More serious risks—such as drooping eyelids or asymmetry—are rare and usually linked to inexperienced injectors. That’s why choosing a medical spa led by a physician like Dr. Lan Nguyen is crucial.

What About Cost?

While Botox, Dysport, and Xeomin are similarly priced per unit, Dysport units are measured differently, meaning you may need more units for the same treatment area. However, this doesn’t necessarily translate to higher costs—your provider will calculate total pricing based on your goals and product choice.

Longevity and Maintenance

The average duration for all three products is 3 to 4 months, although some patients metabolize them faster or slower. With consistent use, some patients may find they can stretch out the time between appointments as muscles remain more relaxed.

How We Can Help

At Daily Glow Spa, our goal isn’t just wrinkle reduction—it’s whole-body rejuvenation. Under the expert care of Dr. Lan Nguyen, we deliver results that go deeper than skin, with a holistic medical approach that supports both beauty and well-being.

Whether you’re exploring neuromodulators for the first time or seeking to refine your current regimen, we’re here to help you navigate the differences between Botox, Dysport, and Xeomin. With our personalized consultations, honest guidance, and medically advanced techniques, we ensure every visit leaves you glowing from the inside out.

Ready to experience the difference? Book your consultation today and discover why our motto is:

Rejuvenate Daily, Shine Always.